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Search for "nucleic acids recognition" in Full Text gives 1 result(s) in Beilstein Journal of Organic Chemistry.

Polarization spectroscopy methods in the determination of interactions of small molecules with nucleic acids – tutorial

Tamara Šmidlehner,
Ivo Piantanida and
Gennaro Pescitelli

Beilstein J. Org. Chem. 2018, 14, 84–105, doi:10.3762/bjoc.14.5

interactions; nucleic acids recognition; vibrational circular dichroism; Review 1. Introduction Many biological molecules are chiral and chromophoric among which the most important examples include proteins and nucleic acids. Moreover, the chiral constituents of natural biopolymers are homochiral, e.g

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Graphical Abstract

Figure 1: Plane polarized light (PP, cyan) as the sum of the left and right circularly polarized light (L-CP,...

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Figure 2: Schematic representation of ligand binding modes to DNA or RNA (left to right: DNA minor groove bin...

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Scheme 1: Principal electronic transitions of nucleobases (uracil is similar to thymine, Thy). The arrows dep...

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Figure 3: Exciton coupling mechanism in its degenerate (top) and non-degenerate version (bottom). a) Chiralit...

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Figure 4: ECD and UV (inset) spectra of poly(dG-dC)–poly(dG-dC) in the B and Z-form, obtained in 59% and 67% ...

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Figure 5: Schematic illustration of an ECD instrument. Legend: S, source; M, monochromator (wavelength select...

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Figure 6: Exciton coupling in the G-quadruplex [d(TG₄T)]₄. For this sequence, the quadruplex is formed by fou...

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Figure 7: Empirical analysis of ECD and flow LD spectra to establish the preferred orientation of a ligand bo...

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Figure 8: CD titration of poly rA-poly rU (left) and poly rU (right) (c(polynucleotide) = 2.0 × 10⁻⁵ mol dm⁻³...

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Figure 9: a) Schematic diagram of a flow LD instrument. b) Definition of the optical factor relating the dire...

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Figure 10: LD spectrum of calf thymus (ct) DNA (c = 2 × 10⁻⁴ M), pH 7, sodium cacodylate buffer, I = 0.05 M.

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Figure 11: Schematic illustration of an FDCD a) and a CPL b) instrument. Legend: S, source; M, monochromator (...

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Figure 12: Minimal model to be considered to simulate the ICD spectrum of an intercalated ligand. ICD will be ...

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Figure 13: Schematic representation of the main steps for calculating the ICD spectrum of a ligand bound to a ...

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Review

Published 08 Jan 2018

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